Table 2.
miR-21 functions in cardiomyopathies.
| Disease conditions | Sample sources | Targets | Functions | References |
|---|---|---|---|---|
| MI | Heart/CMs/MPs | PDCD4 | Apoptosis ↓ Inflammation ↓ |
(33, 34, 36, 68) |
| HF | Heart | PTEN | Angiogenesis/CMs Survival ↑ | (69) |
| DCM | Heart, CMs | Gelsolin | Hypertrophy ↓ | (52) |
| I/R Injury | Heart, CMs | PDCD4/PTEN | Apoptosis ↓ | (56, 70) |
| Valve Replacement | Heart | Apoptosis ↓ | (65) | |
| VMCs | Heart | MAP2K3 | Necrosis/ viral titers ↓ | (71) |
| HR | CMs | PTEN/PDCD4 Akap8/ Bard1 |
Apoptosis ↓ | (30, 61, 70) |
| OGD/ H2O2/ Palmitate | NRCMs/ CPCs H9C2/ CSCs |
PDCD4 | Apoptosis ↓ | (36, 60, 64, 70, 72) |
| MI | Heart/CFs | Smad7/Jagged1/ Spry1 | Fibrosis ↑ | (31, 35, 73) |
| HF | CFs | Spry1 | Fibrosis ↑ | (74) |
| DCM | Heart | SPRY1 | Fibrosis ↑ | (51) |
| I/R injury | CFs | PTEN | Fibrosis ↑ | (55) |
| HHD | Heart | PDCD4 | Fibrosis ↑ | (75) |
| AF | Herat/CFs/CMs | Spry1/Smad7 | Fibrosis/ arrhythmia ↑ | (43–45) |
| CAD | Coronary artery | Plaque instability ↑ | (41) | |
| HG | CFs | DUSP8 | Fibrosis ↑ | (51, 59) |
| Ang-II | CPCs/NRCMs | PDCD4 | Fibrosis/hypertrophy ↑ | (62, 75) |
Myocardial infraction (MI), Viral myocarditis (VMC), Heart Failure (HF), Diabetic cardiomyopathy (DCM), Ischemia-Reperfusion injury (I/R injury), Hypoxia-Reoxygenation (HR), Oxygen-glucose Deprivation (OGD), Hydrogen peroxide (H2O2), Atrial Fibrillation (AF), Coronary artery disease (CAD), Hypertensive heart disease (HHD), High Glucose (HG), Angiotensin II (Ang II), Cardiac Fibroblasts (CFs), Cardiomyocytes (CMs), Macrophages (MPs), Differentiated Cardiac Progenitor Cells (CPCs), Primary Neonatal Rat Cardiac Myocytes (NRCMs), Rat Myoblasts (H9C2), Cardiac Stem Cells (CSCs), Programmed Cell Death 4 (PDCD4), Mitogen-activated Protein Kinase Kinase 3 (MAP2K3), Phosphatase and Tensin Homolog Deleted on Chromosome 10(PTEN), Sprouty Homologue 1 (Spry1), A-kinase Anchoring Protein 8 (Akap8), BRCA1 associated RING domain 1 (Bard1), Dual Specific Phosphatase 8 (DUSP8), SMAD Family Member 7 (Smad 7), Increase ↑, Decrease ↓.