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. 2021 Nov 9;11:21942. doi: 10.1038/s41598-021-01450-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Exosomal miRNA bioinformatic analysis under TGF-β2 stimulation. (A and C) Network of miRNA-mRNA pairs associated with GO terms (A) and with KEGG pathways (C). Triangular and circular nodes represent miRNAs and predicted target mRNAs, respectively. High and low expression are represented in red and blue, respectively. (B and D) Histograms of significantly upregulated signaling pathways were generated according to the results of Gene Ontology (GO) (B) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses (D). The X-axis represents the logarithm of the p-value, and the Y-axis represents the name of the signaling pathways.