. Author manuscript; available in PMC: 2022 Nov 1.

Published in final edited form as: Ophthalmol Retina. 2021 Jul 26;5(11):1061–1073. doi: 10.1016/j.oret.2021.07.006

Table 1.

Phenotypic characteristics used as input for cluster analysis.

defined at AREDS2 baseline visit; all other characteristics in the cross-sectional analyses (apart from GA enlargement rate) were defined at first appearance of geographic atrophy

^†

as described in AREDS2 Report 2 (Danis et al, IOVS 2013)

^‡

defined as the maximum value during follow-up

^§

defined as most common configuration during follow-up (see text)

Abbreviations: AREDS=Age-Related Eye Disease Study; BCVA=best-corrected visual acuity; ETDRS=Early Treatment Diabetic Retinopathy Study; GA=geographic atrophy

Cross-sectional analyses	Longitudinal analyses
Age (years)^*	Age^*
Sex^*	Sex^*
White / non-white^*	White / non-white^*
Educational level (3 levels)^*	Educational level (3 levels)^*
Smoking status (current / former / never)^*	Smoking status (current / former / never)^*
Square root of GA area (mm)	-
GA central involvement (yes / no)	GA central involvement (yes / no)^‡
GA configuration (small / multifocal / horseshoe or ring / solid or unifocal / indeterminate)	GA configuration (small / multifocal / horseshoe or ring / solid or unifocal / indeterminate)^§
GA fellow eye involvement (yes / no)	GA fellow eye involvement (yes / no)^‡
Square root GA enlargement rate (mm/year)	Square root GA enlargement rate (mm/year)
Total drusen area within AREDS grid (7 levels)^†	Total drusen area within AREDS grid (7 levels)^†^‡
Maximum drusen size within AREDS grid (4 levels)^†	Maximum drusen size within AREDS grid (4 levels)^†^‡
Calcified drusen presence (yes / no)	Calcified drusen presence (yes / no)^‡
Reticular pseudodrusen score (0.0–1.0)	Reticular pseudodrusen score (0.0–1.0)^‡
BCVA (ETDRS letter score)	BCVA rate (change in ETDRS letter score/year)