Table 3.
Demographic, phenotypic, and genetic characteristics of the study population.
| Variable | All Subjects (N=598) | |
|---|---|---|
| Age (years): median (IQR) | 75.7 (70.0, 79.8) | |
| Male: n (%) | 258 (43.1) | |
| White: n (%) | 593 (99.2) | |
| Education: n (%) | High School or Less | 211 (35.3) |
| At least some College | 279 (46.7) | |
| Post-graduate | 108 (18.1) | |
| Smoking status: n (%) | Current | 38 (6.4) |
| Former | 310 (51.8) | |
| Never | 250 (41.8) | |
| Central GA: n (%) | 192 (32.1) | |
| Calcified Drusen: n (%) | 260 (43.5) | |
| GA Configuration: n (%) | Small (single patch <1DA) | 368 (61.5) |
| Multifocal | 129 (21.6) | |
| Horseshoe, Ring | 12 (2.0) | |
| Solid (center or not) | 75 (12.5) | |
| Indeterminate | 14 (2.3) | |
| Drusen Area Within the ETDRS Grid: n (%) | < circle C1 | 1 (0.2) |
| < circle C2 | 6 (1.0) | |
| < circle I2 | 8 (1.3) | |
| < circle O2 | 27 (4.5) | |
| < 1/2 DA | 114 (19.1) | |
| < 1 DA | 157 (26.3) | |
| >= 1 DA | 285 (47.7) | |
| Maximum Drusen Size: n (%) | <63 μm (circle C0) | 2 (0.3) |
| <125 μm (circle C1) | 8 (1.3) | |
| <250 μm (circle C2) | 287 (48.0) | |
| >=250 μm (circle C2) | 301 (50.3) | |
| GA in Fellow Eye: n (%) | 153 (25.6) | |
| RPD score: median (IQR) | 0.37 (0.12, 0.78) | |
| Square Root of GA area (mm): median (IQR) | 0.9 (0.6, 1.3) | |
| GA Enlargement from Regression of Square Root of GA area (mm/year): median (IQR) | 0.23 (0.07, 0.46) | |
| Visual acuity (ETDRS letters): median (IQR) | 75.0 (65.0, 82.0) | |
| Follow-up time from first appearance of GA (years): median (IQR) | 2.6 (1.5, 3.4) | |
| Variable | Subjects with genetic data (N=313) | |
| 52 SNP-based Genetic Risk Score: median (IQR) | 15.5 (14.6, 16.4) | |
| Complement GRS: median (IQR) | 8.7 (8.1, 9.2) | |
| Extracellular matrix GRS: median (IQR) | 0.9 (0.8, 1.0) | |
| Lipid metabolism GRS: median (IQR) | 1.8 (1.6, 1.9) | |
| ARMS2 GRS: median (IQR) | 1.1 (0, 1.1) |