Table 5.
Demographic, phenotypic, and genetic characteristics of the longitudinal phenotypic clusters.
| Variable | Cluster G (N=310) | Cluster H (N=288) | |
|---|---|---|---|
| Age (years): median (IQR) | 75.7 (70.0, 79.7) | 75.7 (70.0, 79.9) | |
| Male: n (%) | 169 (54.5) | 89 (30.9) | |
| White: n (%) | 308 (99.4) | 285 (99.0) | |
| Education: n (%) | High School or Less | 111 (35.8) | 100 (34.7) |
| At least some College | 147 (47.4) | 132 (45.8) | |
| Post-graduate | 52 (16.8) | 56 (19.4) | |
| Smoking status: n (%) | Current | 0 (0.0) | 38 (13.2) |
| Former | 310 (100.0) | 0 (0.0) | |
| Never | 0 (0.0) | 250 (86.8) | |
| Central GA: n (%)* | 183 (59.0) | 167 (58.0) | |
| Calcified Drusen: n (%)* | 197 (63.5) | 187 (64.9) | |
| GA Configuration: n (%)† | Small (single patch <1DA) | 128 (41.3) | 119 (41.3) |
| Multifocal | 82 (26.5) | 76 (26.4) | |
| Horseshoe, Ring | 11 (3.5) | 11 (3.8) | |
| Solid (center or not) | 72 (23.2) | 77 (26.7) | |
| Indeterminate | 17 (5.5) | 5 (1.7) | |
| Drusen Area Within the ETDRS Grid: n (%)* | < circle C1 | 0 (0.0) | 0 (0.0) |
| < circle C2 | 0 (0.0) | 0 (0.0) | |
| < circle I2 | 0 (0.0) | 1 (0.3) | |
| < circle O2 | 3 (1.0) | 10 (3.5) | |
| < 1/2 DA | 33 (10.6) | 27 (9.4) | |
| < 1 DA | 84 (27.1) | 58 (20.1) | |
| >= 1 DA | 190 (61.3) | 192 (66.7) | |
| Maximum Drusen Size: n (%)* | <63 μm (circle C0) | 0 (0.0) | 0 (0.0) |
| <125 μm (circle C1) | 0 (0.0) | 1 (0.3) | |
| <250 μm (circle C2) | 95 (30.6) | 82 (28.5) | |
| >=250 μm (circle C2) | 215 (69.4) | 205 (71.2) | |
| GA in Fellow Eye: n (%)* | 151 (48.7) | 128 (44.4) | |
| RPD score: median (IQR)* | 0.64 (0.27, 0.87) | 0.66 (0.28, 0.87) | |
| GA Enlargement from Regression of Square Root of GA area (mm/year): median (IQR) | 0.25 (0.08, 0.51) | 0.21 (0.06, 0.43) | |
| Slope from Regression of visual acuity (ETDRS letters/year): median (IQR) | −1.7 (−4.7, 0.5) | −1.4 (−3.7, 0.7) | |
| Follow-up time from first appearance of GA (years): median (IQR) | 2.6 (1.6, 3.3) | 2.6 (1.3, 3.4) | |
| Variable | Subjects with genetic data (N=313) | ||
| 52 SNP-based Genetic Risk Score: median (IQR) | 15.7 (14.7, 16.4) | 15.4 (14.5, 16.5) | |
| Complement GRS: median (IQR) | 8.7 (8.1, 9.3) | 8.8 (8.1, 9.2) | |
| Extracellular matrix GRS: median (IQR) | 0.9 (0.8, 1.0) | 0.9 (0.7, 1.0) | |
| Lipid metabolism GRS: median (IQR) | 1.7 (1.5, 1.9) | 1.8 (1.6, 1.9) | |
| ARMS2 GRS: median (IQR) | 1.1 (0, 1.1) | 1.1 (0, 1.1) | |
*
defined as the maximum value during follow-up
†
defined as most common configuration during follow-up
Characteristics with apparent differences between clusters are highlighted in bold