Table 2.

Infections

	PI3KCD n=33	PI3KR1 n=7	Combined n=40
RESPIRATORY
Recurrent Sinusitis	25 (75.8%)	2 (28.6%)	27 (67.5%)
Pneumonia	24 (72.7%)	4 (57.1%)	28 (70.0%)
Recurrent URI	20 (60.6%)	4 (57.1%)	24 (60.0%)
Otitis	20 (60.6%)	5 (71.4%)	25 (62.5%)
Dental/oral soft tissue abscesses	7 (21.2%)	0	7 (17.5%)
Thrush	3 (9.1%)	1 (14.3%)	4 (10.0%)
Tonsillitis	1 (3.0%)	0	1 (2.5%)
Ocular infections	1 (3.0%)	1 (14.3%)	2 (5.0%)
VIRAL
Herpesvirus Infection (All)	11 (33.3%)	4 (57.1%)	15 (37.5%)
EBV	7 (21.2%)	1 (14.3%)	8 (20.0%)
HSV	5 (15.2%)	2 (28.6%)	7 (17.5%)
CMV	4 (12.1%)	1 (14.3%)	5 (12.5%)
VZV	3 (9.1%)	2 (28.6%)	5 (12.5%)
Warts	3 (9.1%)	2 (28.6%)	5 (12.5%)
Molluscum	3 (9.1%)	1 (14.3%)	4 (10.0%)
HPV	None	1 (14.3%)	1 (2.5%)
GASTROINTESTINAL
Chronic Diarrhea	4 (12.1%)	4 (57.1%)	8 (20.0%)
Splenic Abscess	1 (3.0%)	1 (14.3%)	2 (5.0%)
Liver Abscess	1 (3.0%)	1 (14.3%)	2 (5.0%)
OTHER
Meningitis	4 (12.1%)	0	4 (10.0%)
Skin Abscess	3 (9.1%)	1 (14.3%)	4 (10.0%)
Endocarditis	1 (3.0%)	0	1 (2.5%)

A large range of infections was exhibited, most commonly bacterial respiratory infections and herpesvirus infections. Opportunistic infections were rare, with only one PI3KCD patient who developed Pneumocystis jirovecci pneumonia. 15.0% of patients reported various abscesses