Figure 6.

Ventricular geometry is an indicator for peak cell stretch (a) and the wall fraction exposed to elevated cell stretch (b). We measure the radius of a sphere fitted to the anterior and posterior horns as a representative marker for ventricular geometry. We observe that peak cell stretch decreases for increasing horn radii and that an increasing wall section experiences elevated cell stretch as horn radius increases. Our observations suggest that younger brains with sharper ventricular horns, i.e., smaller horn radii, experience higher ependymal cell loading while aged brains (with larger horn radii) experience lower cell loads but elevated stretches on larger wall sections, i.e., increased width of cell stretch.