Table 2.
Characteristics | Total | Patients with ICD code | Patients without ICD codes | Stand Diff |
---|---|---|---|---|
Total | 73,644 | 16,280 | 57,364 | |
Days before index date, mean (SD) | 45.9 (53.7) | 45.9 (53.7) | - | |
Days after index date, mean (SD) | 71.5 (51.9) | 71.5 (51.9) | - | |
Index year: 2014, n(%) | 36,518 (49.6) | 5,920 (36.4) | 30,598 (53.3) | 0.34 |
Index year: 2016, n(%) | 37,126 (50.4) | 10,360 (63.6) | 26,766 (46.7) | −0.34 |
Demographics | ||||
Age, mean years (SD) | 71.1 (11.1) | 67.5 (12.0) | 72.1 (10.7) | 0.40 |
Male, n(%) | 30,275 (41.1) | 6,700 (41.2) | 23,575 (41.1) | 0.00 |
White, n(%) | 64,099 (87.0) | 13,663 (83.9) | 50,436 (87.9) | 0.12 |
Non-white, n(%) | 9,545 (13.0) | 2,617 (16.1) | 6,928 (12.1) | −0.12 |
Co-severities | ||||
BMI, median (IQR) | 27.5 (24.2 to 31.5) | 32.6 (28.5 to 37.3) | 26.6 (23.6 to 29.8) | −0.10 |
BMI, mean (SD) | 28.4 (6.1) | 33.2 (7.4) | 27.0 (4.9) | −0.99 |
Smoking, n(%) | 9,205 (12.5) | 3,237 (19.9) | 5,968 (10.4) | −0.27 |
Drug abuse, n(%) | 1,858 (2.5) | 735 (4.5) | 1,123 (2.0) | −0.14 |
Alcohol abuse, n(%) | 1,889 (2.6) | 684 (4.2) | 1,205 (2.1) | −0.12 |
Hypertension, n(%) | 42,345 (57.5) | 11,218 (68.9) | 31,127 (54.3) | −0.30 |
Hyperlipidemia, n(%) | 34,994 (47.5) | 8,994 (55.2) | 26,000 (45.3) | 0.20 |
Type 2 Diabetes, n(%) | 9,282 (12.6) | 3,999 (24.6) | 5,283 (9.2) | −0.42 |
Cardiovascular disease, n(%) | 17,450 (23.7) | 4,980 (30.6) | 12,470 (21.7) | −0.20 |
Heart failure, n (%) | 6,373 (8.7) | 2,270 (13.9) | 4,103 (7.2) | −0.22 |
Hypertension, n (%) | 42,345 (57.5) | 11,218 (68.9) | 31,127 (54.3) | −0.30 |
Ischemic heart disease, n (%) | 12,768 (17.3) | 3,565 (21.9) | 9,203 (16.0) | −0.15 |
Stroke, n (%) | 4,378 (5.9) | 1,107 (6.8) | 3,271 (5.7) | −0.05 |
TIA, n (%) | 1,377 (1.9) | 355 (2.2) | 1,022 (1.8) | −0.03 |
PVD, n (%) | 4,233 (5.7) | 1,226 (7.5) | 3,007 (5.2) | −0.09 |
Other cerebrovascular disease, n (%) | 1,271 (1.7) | 331 (2.0) | 940 (1.6) | −0.03 |
COPD, n(%) | 6,659 (9.0) | 2,063 (12.7) | 4,596 (8.0) | −0.15 |
Asthma, n(%) | 6,155 (8.4) | 2,250 (13.8) | 3,905 (6.8) | −0.23 |
Sleep apnea, n (%) | 4,776 (6.5) | 2,492 (15.3) | 2,284 (4.0) | −0.39 |
GERD, n (%) | 12,461 (16.9) | 3,789 (23.3) | 8,672 (15.1) | −0.21 |
Osteoarthritis, n (%) | 15,293 (20.8) | 4,308 (26.5) | 10,985 (19.1) | −0.18 |
NAFLD or NASH, n (%) | 1,293 (1.8) | 633 (3.9) | 660 (1.2) | −0.17 |
Bariatric surgery, n(%) | 135 (0.2) | 88 (0.5) | 47 (0.1) | −0.07 |
Malignant cancer, n(%) | 18,010 (24.5) | 3,746 (23.0) | 14,264 (24.9) | 0.04 |
Depression, n (%) | 12,305 (16.7) | 3,937 (24.2) | 8,368 (14.6) | −0.24 |
Combined co-severity score, mean (SD) | 1.7 (2.6) | 2.3 (3.0) | 1.5 (2.4) | −0.29 |
Frailty, n(%) | ||||
<0.1 | 6,871 (9.3) | 853 (5.2) | 6,018 (10.5) | 0.20 |
0.1-<0.2 | 55,426 (75.3) | 11,562 (71.0) | 43,864 (76.5) | 0.13 |
>=0.2 | 11,347 (15.4) | 3,865 (23.7) | 7,482 (13.0) | −0.28 |
Medications | ||||
Antihypertensives, n(%) | 34,744 (47.2) | 8,592 (52.8) | 26,152 (45.6) | 0.14 |
Beta blocker, n(%) | 27,752 (37.7) | 6,808 (41.8) | 20,944 (36.5) | −0.11 |
CCB, n(%) | 16,787 (22.8) | 4,185 (25.7) | 12,602 (22.0) | −0.09 |
Diuretics, n(%) | 11,063 (15.0) | 3,681 (22.6) | 7,382 (12.9) | 0.26 |
Nitrates, n(%) | 3,374 (4.6) | 1,049 (6.4) | 2,325 (4.1) | −0.10 |
Other hypertension drugs, n(%) | 5,200 (7.1) | 1,597 (9.8) | 3,603 (6.3) | −0.13 |
Statins, n(%) | 37,159 (50.5) | 8,999 (55.3) | 28,160 (49.1) | −0.12 |
Non-insulin Antidiabetic drugs, n(%) | 9,602 (13.0) | 3,558 (21.9) | 6,044 (10.5) | −0.31 |
Insulin, n (%) | 2,828 (3.8) | 1,282 (7.9) | 1,546 (2.7) | −0.23 |
Antiobesity medications, n(%) | 121 (0.2) | 46 (0.3) | 75 (0.1) | −0.04 |
Anticoagulants, n(%) | 9,154 (12.4) | 2,571 (15.8) | 6,583 (11.5) | −0.13 |
Antiplatelets, n(%) | 3,573 (4.9) | 963 (5.9) | 2,610 (4.6) | −0.06 |
COPD medications, n(%) | 16,121 (21.9) | 4,527 (27.8) | 11,594 (20.2) | −0.18 |
PPI or H2 blocker, n (%) | 22,851 (31.0) | 6,450 (39.6) | 16,401 (28.6) | 0.23 |
Opioids, n (%) | 14,174 (19.2) | 4,325 (26.6) | 9,849 (17.2) | −0.23 |
NSAIDS, n (%) | 10,280 (14.0) | 2,971 (18.2) | 7,309 (12.7) | −0.15 |
Antidepressant, n(%) | 22,032 (29.9) | 6,253 (38.4) | 15,779 (27.5) | −0.23 |
Healthcare utilization | ||||
Hospitalizations, mean (SD) | 0.2 (0.6) | 0.4 (0.8) | 0.2 (0.5) | −0.30 |
ED visits, mean (SD) | 0.5 (1.1) | 0.7 (1.5) | 0.4 (0.9) | −0.24 |
Outpatient visits, mean (SD) | 5.5 (4.8) | 6.7 (5.2) | 5.2 (4.6) | −0.31 |
Number of drugs, mean (SD) | 7.4 (4.8) | 9.3 (5.5) | 6.8 (4.4) | −0.50 |
Abbreviations: standard deviation (SD), primary care physician (PCP), standardized difference (Stand. Diff.), body mass index (BMI), International classification of diseases (ICD), chronic obstructive pulmonary disease (COPD), non-alcoholic fatty-liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), gastroesophageal reflux disease (GERD), calcium-channel blockers (CCB), nonsteroidal anti-inflammatory drugs (NSAIDS), proton-pump inhibitors (PPI), emergency department (ED)