TABLE 4.
Final parameter estimates and bootstrap for the UNC model
| Hazendonk et al. | Model | Bootstrap | UNC | Model | Bootstrap |
|---|---|---|---|---|---|
| Minimization successful | N/A | 799/1000 | Minimization successful | N/A | 1000/1000 |
| CL (ml/h)a | 150 | 180 (46, 600) | CL (ml/h)b | 190 | 190 (160, 220) |
| CL: Effect of agec | −.17 | −.51 (−1.5, −.016) | CL: Effect of Aged | −.013 | −.013 (−.024, −.0031) |
| CL: Effect of blood type | 1.26 | .92 (.66, 1.3) | |||
| CL: Effect of severity of surgical procedure | .93 | 1.2 (.34, 2.2) | |||
| V1 (ml) | 2810 | 4100 (2600, 5800) | V1 (ml) | 5800 | 5800 (4300, 7600) |
| V1: Effect of age | −.09 | −.65 (−1.5, .47) | |||
| V2 (ml) | 1900 | 1300 (570, 95000) | |||
| Q (ml/h) | 160 | 72 (28, 1400) | |||
| Additive error (IU/ml) | (Center-based) | .47 (.41, .53) | |||
| Proportional error (%) | (Center-based) | .0033 (.0032, .0033) | Proportional error (%) | 32 | 32 (27, 37) |
| IIV on CL (%) | 26 | 33 (21, 82) | IIV on CL (%) | 47 | 45 (33, 64) |
| Covariance between CL and V1 | .46 | .48 (−.14, .88) | |||
| IIV on V1 (%) | 36 | 69 (44, 91) | IIV on V1 (%) | 74 | 72 (48, 96) |
Abbreviations: CL, clearance; IIV, inter-individual variability; Q, intercompartmental clearance between V1 and V2; UNC, University of North Carolina Medical Center; V1, central compartment volume of distribution; V2, peripheral compartment volume of distribution.
The final estimates for the parameters from the population PK model.
a
Expected clearance for a 68 kg, 40 year-old, non-O blood type, minor surgery patient.
b
Expected clearance for a 70 kg, 57 year-old patient.
c
As an exponent on age centered at 40 year-old
d
As fractional change per year.