Table 2:

Evidence for treatment and knowledge gaps in treating obesity, GERD, and OSA in asthma

	Evidence for treatment	Knowledge gaps
Obesity	Weight loss • Increased asthma quality of life, asthma control, improved lung function Physical activity • Increased asthma control Improved diet quality • Increased fruits and vegetables associated with decreased exacerbations • Increased soluble fiber associated with increased asthma control	• Effective weight loss strategies • Targeted pharmacologic therapies for metabolic abnormalities including increased HDL, L-citrulline supplementation, decreased triglycerides • Gut microbiome manipulation • Better understanding of immunomodulatory effects and possible treatment targeting adipokines
OSA	CPAP for sleep apnea • Improves asthma quality of life • Improved asthma control and decreased daytime symptoms in observational studies	• Impact of CPAP treatment in preventing incident asthma • Utility of routine screening for OSA among asthmatics
GERD	Treating symptomatic GERD may improve • Asthma quality of life • Asthma symptoms	• Benefit of screening for and treating asymptomatic GERD • Treatment duration • Impact of medical vs surgical treatment for GERD