Table 1.
Bootstrapped (n = 100) test set chronic pain ROC performance for all six biomarker models per bone, as well as an average ensemble across all bones.
| Biomarker type | Biomarker model | Test set ROC (sensitivity/specificity/AUC) (95% CI) | |||
|---|---|---|---|---|---|
| Patella | Tibia | Femur | PTF | ||
| Single | Cartilage T2 | 58.9 (58.3, 59.5) | 49.1 (48.6, 49.7) | 65.7 (65.3, 66.2) | 62.7 (62.2, 63.2) |
| 75.4 (75.0, 75.8) | 77.5 (77.2, 77.9) | 65.1 (64.7, 65.6) | 71.7 (71.4, 72.1) | ||
| 71.0 (70.5, 71.4) | 68.3 (68.0, 68.7) | 70.9 (70.5, 71.3) | 73.7 (73.4, 74.0) | ||
| Cartilage thickness | 55.7 (55.1, 56.2) | 48.1 (47.5, 48.7) | 55.5 (55.0, 55.9) | 54.5 (54.0, 55.0) | |
| 72.2 (71.8, 72.6) | 81.3 (81.0, 81.6) | 77.2 (76.8, 77.5) | 79.2 (78.8, 79.5) | ||
| 68.4 (68.1, 68.8) | 70.7 (70.4, 71.1) | 72.1 (71.7, 72.4) | 72.8 (72.5, 73.2) | ||
| Bone shape | 53.6 (53.1, 54.1) | 50.8 (50.3, 51.3) | 57.6 (57.1, 58.1) | 56.6 (56.1, 57.1) | |
| 79.0 (78.6, 79.4) | 78.8 (78.4, 79.1) | 77.7 (77.4, 78.1) | 80.0 (79.7, 80.4) | ||
| 70.6 (70.3, 71.0) | 70.3 (69.9, 70.6) | 73.6 (73.3, 74.0) | 74.2 (73.9, 74.5) | ||
| Fusion | Morphological bone and cartilage fusion | 61.9 (61.5, 62.4) | 50.7 (50.3, 51.2) | 50.8 (50.3, 51.4) | 53.7 (53.2, 54.1) |
| 69.8 (69.4, 70.2) | 82.5 (82.2, 82.8) | 79.5 (79.1, 79.8) | 82.1 (81.8, 82.4) | ||
| 71.6 (71.3, 72.0) | 72.5 (72.1, 72.8) | 71.7 (71.3, 72.0) | 74.4 (74.1, 74.8) | ||
| Morphological and compositional cartilage fusion | 58.8 (58.3, 59.3) | 43.1 (42.6, 43.6) | 50.7 (50.1, 51.2) | 54.4 (53.9, 54.8) | |
| 67.4 (67.0, 67.9) | 82.1 (81.8, 82.4) | 81.3 (81.0, 81.7) | 79.2 (78.9, 79.6) | ||
| 68.1 (67.7, 68.4) | 68.9 (68.6, 69.3) | 73.3 (73.0, 73.7) | 73.1 (72.7, 73.4) | ||
| All biomarkers fusion | 48.8 (48.3, 49.4) | 47.1 (46.6, 47.6) | 52.9 (52.3, 53.5) | 50.3 (49.8, 50.7) | |
| 77.8 (77.5, 78.2) | 82.1 (81.7, 82.4) | 79.2 (78.8, 79.5) | 82.3 (82.0, 82.6) | ||
| 69.9 (69.6, 70.3) | 73.0 (72.6, 73.3) | 71.6 (71.3, 72.0) | 73.8 (73.4, 74.1) | ||
Sensitivity, specificity, and AUC values are shown respectively, along with their corresponding 95% confidence intervals.
The best performances per bone and ensemble are bolded. PTF = Patella + Tibia + Femur ensemble. Result metrics are for the first timepoint for each patient.