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. Author manuscript; available in PMC: 2022 May 15.
Published in final edited form as: J Immunol. 2021 Oct 4;207(10):2399–2404. doi: 10.4049/jimmunol.2100608

Figure 2. Infection with SARS-CoV-2 elicits tissue resident T cell responses.

Figure 2.

hACE2 mice were intranasally infected with 102 PFU of SARS-CoV-2. Twenty-eight days later, the A) percent resident of CD4+, B) number of resident CD4+ Teff, C) percent resident of CD8+, D) number of resident CD8+ Teff, E) percent CD69+ of resident CD4+ from SCV2 infected mice, F) percent expressing CD69 and/or CD103 of resident CD8+ from SCV2 infected mice, G) number of circulating CD4+ Teff, and H) number of circulating CD8+ Teff was determined using flow cytometry. Uninfected mice served as negative controls. n=12-13 mice/group and are combined from 3 independent experiments for A-D, G, H; n=22 mice combined from 2 independent experiments for E, F. Each point represents an individual mouse; error bars indicate SEM. Statistical significance was determined using an unpaired t-test; * indicates p < 0.05.