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. Author manuscript; available in PMC: 2022 Nov 8.
Published in final edited form as: Cancer Cell. 2021 Oct 7;39(11):1531–1547.e10. doi: 10.1016/j.ccell.2021.09.003

Figure 4: HGF-MET and FGF-FGFR are two mainstream CAF-cancer crosstalk contributing to resistance.

Figure 4:

A. A set of 38 PDFs (all derived from EGFR+ NSCLC) conditioned media was tested across 12 EGFR+ cancer cell lines in the presence of EGFRi (E) alone or EGFRi in combination with METi (M), FGFRi (F) or both. Top bars are average resistance level of a given cancer cell line tested across all PDFs, and side bars are average rescue effect of a given PDF tested across all cancer lines. B. Nude mice implanted with MGH707 cancer cells alone or together with CCD19-Lu fibroblasts were treated as indicated 10 days after injection for 3 days. Given the extra tumor volume due to fibroblasts, Ki67 and phospho-S6 IHC staining in cancer cells, instead of the tumor size, were measured. Six xenograft tumors were quantified in each treatment group. * p < 0.05, ** p < 0.01, **** p < 0.0001, two-tailed t test. See also Figures S5.