Table 1:
Clinical characteristics of the 1088 individuals enrolled in the cohort study stratified according to T. cruzi-serologic tests and the presence of Chagas cardiomyopathy at baseline and at follow-up.
| Time | Visit 1 (Baseline) | Visit 2 (Follow-up) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Participant characteristics |
T. cruzi- seronegative (n=488) |
T. cruzi– seropositive (n=499) |
Chagas cardiomyopathy (n=101) |
P-value |
T. cruzi- seronegative (n=285) |
T. cruzi– seropositive (n=330) |
Chagas cardiomyopathy (n=20) |
P-value | |
| Age, years | 49 (42-58) | 48 (40-57) | 48 (42-54) | 0.237 | 59 (52-66) | 56 (50-65) | 55 (50-61) | 0.054 | |
| Male sex | 241 (49.4) | 261 (52.3) | 60 (59.4) | 0.172 | 140 (49.1) | 159 (48.2) | 13 (65.0) | 0.344 | |
| Clinical history | |||||||||
| Diabetes | 24 (4.9) | 27 (5.4) | 6 (5.9) | 0.870 | 38 (13.3) | 42 (12.7) | 3 (15) | 0.504 | |
| Hypertension | 119 (24.4) | 113 (22.6) | 36 (35.6) | 0.072 | 102 (35.8) | 128 (38.8) | 9 (45) | 0.648 | |
| Chronic kidney disease | 15 (3.1) | 15 (3.0) | 10 (9.9) | 0.009 | 15 (5.3) | 21 (6.4) | 2 (10) | 0.793 | |
| Suspected CAD* | 5 (1.0) | 3 (0.6) | 12 (11.9) | 0.001 | 10 (3.5) | 11 (3.3) | 2 (10) | 0.039 | |
| Symptoms - NYHA functional class | |||||||||
| Class I | 469 (96.1) | 461 (92.4) | 60 (59.3) | <0.001 | 262 (91.9) | 298 (90.3) | 9 (45.0) | <0.001 | |
| Class II | 18 (3.7) | 35 (7.0) | 27 (26.7) | 20 (6.9) | 24 (7.3) | 8 (40.0) | |||
| Class III/IV | 1 (0.2) | 3 (0.6) | 14 (13.9) | 3 (1.2) | 8 (2.4) | 3 (15.0) | |||
| Smoking history | Never | 255 (52.2) | 283 (56.7) | 47 (46.5) | 0.014 | 165 (57.9) | 215 (65.2) | 9 (45.0) | 0.119 |
| Past | 158 (32.4) | 161 (32.3) | 46 (45.5) | 77 (27.0) | 65 (19.7) | 6 (30.0) | |||
| Current | 75 (15.4) | 55 (11.0) | 8 (8.0) | 43 (15.1) | 50 (15.2) | 5 (25.0) | |||
| BMI, kg/m2 | 27 (25-30) | 26 (24-29) | 26 (23-28) | <0.001 | 27 (25-31) | 27 (25-30) | 26 (23-31) | 0.307 | |
| Obesity (BMI>30) | 127 (26.0) | 94 (18.8) | 14 (13.9) | 0.002 | 85 (29.8) | 80 (24.2) | 5 (25.0) | 0.274 | |
| Heart rate, bpm | 70 (60-75) | 65 (60-70) | 60 (58-70) | <0.001 | 73 (65-80) | 70 (63-78) | 67 (59-72) | 0.002 | |
| SBP, mmHg | 125 (115-140) | 125 (114-140) | 122 (107-134) | 0.003 | 130 (120-145) | 130 (116-143) | 110 (102-118) | <0.001 | |
| DBP, mmHg | 79 (65-88) | 76 (65-85) | 80 (69-90) | 0.088 | 80 (70-88) | 80 (70-85) | 71 (61-80) | 0.004 | |
| NT-ProBNP, pg/mL | 38 (23-65) | 48 (27-90) | 746 (335-2267) | <0.001 | 37 (23-61) | 46 (24-84) | 360 (129-550) | <0.001 | |
*
Chest pain suggestive of ischemic heart disease.
BMI: body mass index; CAD: coronary artery disease; DBP: diastolic blood pressure; NYHA: New York Heart Association; SBP: systolic blood pressure