Table 4:
Characteristics of seropositive and seronegative blood donors without cardiomyopathy at the baseline visit.
|
T. cruzi-seronegative donors (n=471) |
T. cruzi-seropositive donors (n=385) |
p-value | ||
|---|---|---|---|---|
| Age, years* | 49 (42-58) | 48 (40-56) | 0.128 | |
| Male sex | 231 (49.0) | 187 (48.6) | 0.890 | |
| Body Mass Index, Kg/m2 | 26.9 (25-30) | 26.6 (24-29) | 0.014 | |
| NYHA functional class | I | 454 (96.4) | 357 (92.8) | 0.020 |
| II/III | 17 (3.6) | 28 (7.2) | ||
| Heart rate (bpm) | 68 (60-75) | 65 (60-72) | 0.005 | |
| Systolic blood pressure (mmHg) | 125 (114-140) | 125 (114-140) | 0.943 | |
| Diastolic blood pressure (mmHg) | 79 (65-88) | 76 (68-86) | 0.740 | |
| Laboratory measurements | ||||
| Low-density lipoprotein, mg/dL) | 124 (100-151) | 118 (96-145) | 0.087 | |
| 46 (38-55) | 48 (41-58) | 0.015 | ||
| High-density lipoprotein, mg/dL | ||||
| Triglycerides, mg/dL | 125 (89-176) | 116 (80-167) | 0.024 | |
| Glycemia, mg/dL | 86 (80-97) | 87 (79-95) | 0.676 | |
| Myoglobin, ng/ml | 35.5 (30.0-50.0) | 36.2 (29.3 - 44.3) | 0.913 | |
| Troponin-I, ng/dl | 0.01 (0.01 -0.01) | 0.01 (0.01 -0.01) | 0.195 | |
| CK-MB, ng/dl | 0.68 (0.41-1.18) | 0.78 (0.47-1.25) | 0.043 | |
| NT-ProBNP, pg/mL | 36.6 (23 - 61) | 42.9 (24 - 72) | 0.009 | |
| ECG parameters | ||||
| QRS duration (ms) | 88 (82-94) | 86 (80-94) | 0.209 | |
| PR duration (ms) | 156 (142-168) | 158 (142-174) | 0.252 | |
| QTc calculated (ms) | 427 (410-441) | 425 (409-441) | 0.564 | |
| Low QRS amplitude | 9 (1.9) | 15 (3.9) | 0.080 | |
| First degree AV block | 3 (0.6) | 10 (2.6) | 0.020 | |
| Sinus bradycardia ā„40 bpm | 133 (28.2) | 125 (32.5) | 0.176 | |
| Minor isolated ST-T abnormalities | 37 (7.9) | 47 (12.2) | 0.033 | |
| Isolated ventricular premature beats | 3 (0.6) | 2 (0.5) | 0.826 | |
| Echocardiographic data | ||||
| LV end-diastolic diameter (mm) | 45 (41-49) | 45 (42-49) | 0.639 | |
| LV end-systolic diameter (mm) | 29 (27-32) | 30 (27-33) | 0.993 | |
| LV ejection fraction (%) | 63 (60-65) | 63 (60-65) | 0.274 | |
| LA diameter, mm | 34 (32-37) | 35 (32-37) | 0.201 | |
| LA volume, mL/m2 | 26.5 (22.9-30.6) | 28.7 (22.9-30.6) | 0.001 | |
| LV mass, g/m2 | 76 (64-90) | 80 (67-89) | 0.013 | |
| Mitral inflow E, cm/s | 70 (58-80) | 68 (56-82) | 0.818 | |
| Mitral inflow A, cm/s | 57 (48-70) | 59 (48-71) | 0.394 | |
| Deceleration time, ms | 197 (166-233) | 194 (159-227) | 0.220 | |
| E/A ratio | 1.2 (1.0-1.5) | 1.2 (1.0-1.4) | 0.672 | |
| E/e' ratio | 6 (5-8) | 6 (5-7) | 0.352 | |
| Right atrial area, cm2 | 14 (12-15) | 14 (12-15) | 0.554 | |
*
Age at the time of the cardiovascular assessment (baseline visit).
Data are expressed as absolute numbers (percentage) or median (interquartile range)
Abbreviations: CK-MB: creatine kinase isoenzyme MB; E/eā: ratio of the early diastolic transmitral flow velocity to early diastolic mitral annular velocity (average at septal and lateral mitral annulus); LA: left atrial; LV: left ventricular; NT-ProBNP: B-type natriuretic peptide; NYHA: New York Heart Association