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. 2021 Oct 27;3(4):fcab261. doi: 10.1093/braincomms/fcab261

Figure 1.

Figure 1

Comparison of human and mouse VGF mRNA expression from the Allen Brain Atlas. (A) VGF mRNA expression data were downloaded from the Allen Mouse Brain Atlas; https://celltypes.brain-map.org/rnaseq/mouse (Accessed 03/30/2020). These data represent log2 VGF mRNA expression intensity in 265 different cell types across the whole mouse cortex and hippocampus obtained through single cell RNA-sequencing. Data were sorted by VGF expression and 27 representative cell types were included based on the following criteria: those with the highest VGF expression across a range of brain regions, different neuronal subtypes, glial cells and neurovascular unit cells to ensure a representative sample. (B) VGF mRNA expression data were downloaded from the Allen Human Brain Atlas; https://celltypes.brain-map.org/rnaseq/human/cortex (Accessed 03/30/2020). These data represent log2 VGF mRNA expression intensity in 120 different cell types across multiple human cortical regions (middle temporal gyrus, anterior cingulate gyrus, primary visual cortex, primary motor cortex, primary somatosensory cortex and primary auditory cortex) obtained through single nucleus RNA-sequencing. Data were sorted by VGF expression and 19 representative cell types were included based on the same criteria from the mouse atlas to ensure a representative sample. For each cell type examined, L refers to the layer(s) of the cortex where that cell type was identified along with their associated marker genes in italics. (C) Medial view and (D) lateral view of the predicted whole-brain mRNA expression of VGF using microarray data from the Allen Human Brain Atlas on the surface of the left cortical hemisphere. Colour scales represent log2 mRNA expression intensity and data were accessed from http://www.meduniwien.ac.at/neuroimaging/mRNA.html (Accessed 04/10/2020). Act = activated; Art = arterial; Astro = astrocyte; Cere = cerebellum; CC = cerebral cortex; Cho = cholinergic; Cor = cortex; DRG = dorsal root ganglion; Endo = endothelial cell; Exc = excitatory; Glut proj = glutamatergic projection; GL = granular layer; HB = hindbrain; HC = hippocampus; HT = hypothalamus; Inh = inhibitory; IN = interneuron; LRIN = long-range interneurons; Mat = mature; MG = microglia; MB, midbrain; NFL1 = neurofilament 1; Neu = neuron; Olf = olfactory; Olig = oligodendrocyte; OPC = oligodendrocyte progenitor cell; Ore = orexin-producing; Pep = peptidergic; Peri = pericyte; PV mac = perivascular macrophages; Sel = selective; Ser = serotonergic; SC = spinal cord; Tel = telencephalon; Thal = thalamus; VEC = vascular endothelial cells; VLMC = vascular and leptomeningeal cell.