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Conceptual model of IRF-3 cellular localization. Prior to infection, the dominant effect of the NES results in cytoplasmic localization of IRF-3 (left). Following infection, phosphorylation of IRF-3 results in nuclear association with CBP or p300. The CBP/p300 binding results in the sequestration of the IRF-3 in the nucleus to form the DRAF1 transcription factor (right).
