Table 2.
Interaction of curcumin with amphotericin B, itraconazole, and co-trimoxazole
| CUR + AmB | CUR + ITZ | CUR + CMX | |||
|---|---|---|---|---|---|
| MICCUR | 3.90 | MICCUR | 3.90 | MICCUR | 3.90 |
| MICAmB | 3.90 | MICITZ | 0.007 | MICCMX | 1000 |
| MICCUR combined | 0.96 | MICCUR combined | 0.96 | MICCUR combined | 1.95 |
| MICAmB combined | 0.24 | MICITZ combined | 0.001 | MICCMX combined | 62.5 |
| FIC index | 0.31 | FIC index | 0.50 | FIC index | 0.56 |
| Interaction | Synergistic | Interaction | Synergistic | Interaction | Additive |
MIC, minimal inhibitory concentration; FIC, fractional inhibitory concentration; CUR, curcumin; AmB, amphotericin B; ITZ, itraconazole; CMX, co-trimoxazole. MIC values are expressed in μg/mL