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. 2021 Nov 9;11:21936. doi: 10.1038/s41598-021-01334-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Venn diagram showing identified proteins (Swissprot, human) compared with the top 100 identified EV-associated proteins from Vesiclepedia database. (b) Selected gene ontology analyses of the identified proteins sorted by gene count. (c) Principal component analysis of all individual samples analyzed by MS, HIV + T2D in green (n = 16), T2D only in purple (n = 9), HIV only in blue (n = 14) and controls in red (n = 7). Open squares are patient group pools. (d) Ingenuity Pathway Analysis showing the top upstream regulators for the differentially abundant proteins in the sample groups (Supplementary File 1).