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. 2021 Oct 27;12:745058. doi: 10.3389/fphys.2021.745058

FIGURE 1.

FIGURE 1

Empagliflozin treatment reduces bodyweight and promotes thermogenesis in KKAy mice. Eight-week-old male KKAy mice (n = 6 per group) were administered saline (DM) or empagliflozin (DM + Empa) for 8 weeks. (A) Representative images of mice in 2 groups after 8 weeks of treatment; and (B) bodyweights of the mice during 8 weeks of treatment. (C) Changes in blood glucose as detected by IPGTT after 8 weeks of treatment, and (D) postprandial blood glucose levels during 8 weeks of treatment. (E) Body temperature during a 4-hour cold test at 4°C. (F,H) Representative images of hematoxylin staining, and (G,I) representative images of pWAT and eWAT in mice after 8 weeks of treatment. Scale bar represents 100 μm in (F,H) and 10 mm in (G,I). Data are presented as the mean ± SEM. #P < 0.05 vs. the DM group. pWAT, perirenal white adipose tissue; eWAT, epididymal white adipose tissue. IPGTT, Intraperitoneal glucose tolerance test.