Online-Only Table 8.

PacBio Sequel II Whole Genome Sequencing data sets for fresh DNA extracted from HCC1395BL and HCC1395 cell lines.

Sample ID	Sample	Biosample	Platform	Machine model	library Protocol (Input amount)	Total Reads	Total Bases (Bps)	Total Mapped Reads	Percent Total Mapped Reads	Percent of PCR duplidate(mapped reads)	Mean Coverage Depth	Mean Coverage Depth SD	Percent of Coverage >  = 5X	Percent GC	Median Read Lengh	Raw Coverage
PBO_Normal	HCC1395BL	Fresh cells	PacBio_Sequel	PacBio_Sequel II	Preparing >30 kbp SMRTbell Libraries Using Megarupter Shearing and Blue Pippin Size-Selection for PacBio RS II and Sequel Systems	21,935,561	131,842,758,047	16,759,622	76.40	2.46	44.17	33.25	92.29	41.14	8,050	44
PBO_Tumor	HCC1395	Fresh cells	PacBio_Sequel	PacBio_Sequel II	Preparing >30 kbp SMRTbell Libraries Using Megarupter Shearing and Blue Pippin Size-Selection for PacBio RS II and Sequel Systems	18,835,934	116,009,882,995	16,273,225	86.39	2.58	38.95	47.35	91.62	41.57	8,050	39

Libraries were made from PacBio library preparation and sequencing library protocol.