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. 2021 Nov 9;12:6463. doi: 10.1038/s41467-021-26654-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Pictorial representation of the feeding regime. SD, standard diet (black symbols); LCC, low-calorie cycles (blue symbols); FMD, fasting-mimicking diet (purple symbols). Following a 4-day period of reduced calorie intake, mice were returned to ad libitum diet (AL) for 10 days before initiating a new round of 4:10 fasting-refeeding cycle for a total of 11 cycles. b Body weight trajectories as percent change from baseline (SD, n = 16–18; LCC, n = 19; FMD, n = 17–18). c Cumulative percent body weight changes from baseline to cycle 11 (SD, n = 16; LCC, n = 19; FMD, n = 18). Data are represented as box plot [center line, median; box limits, upper and lower quartiles; whiskers minimum and maximum values]. d Average percent body weight change during a representative 4:10 cycle (n = 11 cycles). Body weight measurements were taken at days 1–4, 7, 10, and 14 of each cycle; e Average food consumption (kCal) on each day of a representative 4:10 cycle (n = 11 cycles). f Cumulative food consumption (kCal) from baseline to cycle 11 (SD, n = 16; LCC, n = 19; FMD, n = 18); g Measures of body fat and (h) lean mass by NMR, and (i) lean-to-fat ratio calculation during cycle 4. Measures for SD, LCC and FMD groups were collected on day 4, while the measures for LCC-RF and FMD-RF were acquired on day 14. Comparison by one-way ANOVA: *, p < 0.05 vs. SD; #, p < 0.05 vs. LCC or FMD, respectively (SD, n = 18; LCC, n = 14; LCC-RF, n = 19; FMD, n = 12; FMD-RF, n = 18); j Percent change in fat mass from baseline (Bsl) during the refed phase of cycles 4 and 10, respectively (SD, n = 15/15/13; LCC, n = 17/17/15; FMD, n = 16/16/16). *, p < 0.05 vs. SD.