Table 1.
Repurposed drugs with anti-viral activity that also affect potassium balance.
| Drug | Human target | Anti-viral activity | Indication | Affects | Reference |
|---|---|---|---|---|---|
| Camostat | Cell Entry | (44, 45) | Pancreatitis | Elevates Na+:K+ ratio | (46) |
| Chloroquine | Cell Entry | (47) | Malaria, immune modulation | Blocks hERG K+ channels | (48) |
| Hydroxy chloroquine |
Cell Entry | (34, 47) | Malaria, immune modulation | Blocks hERG K+ channels | (48) |
| Loratadine | SLC6A15 | (49) | Antihistamine | Kv1.5, outward current | (50, 51) |
| Nafamostat | Cell Entry | (52) | Pancreatitis | Can induce hyperkalemia, by suppressing the Na-K ATPase dependent pathway | (53) |
| Pioglitazone | CISD1 | (54) | Diabetes | Remodeling of Kv1.5 & Kv4.2 | (55) |
| YH-1238 | H+, K+ ATPase Proton Pump | (35) | Phase I | H+,K+-ATPase (ATP4A, ATP4B) | (35) |