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. 2021 Nov 9;12:6365. doi: 10.1038/s41467-021-26576-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Aggregate Observed(O)/Expected(E) Hi-C matrices centered on CX-5461 induced MERVL genes in control, CX-5461 treated mES cells and mouse embryos throughout mouse pre-implantation embryonic development. GEO accession codes GSE166041, GSE63525, and GSE82185. b Representative 40 kb Hi-C O/E interaction matrices of a MERVL loci located at TAD boundaries (chr7:97,113,503–97,122,376) are shown as heatmaps, along with the insulation score and genome browser tracks of RNA-Seq, H3K9me3, H3K27me3, H3K4me3, and H3K27ac ChIP-Seq signals of the expanded genomic region containing the TAD boundary (arrows) in control and CX-5461 treated mES cells as well as in mouse early embryos. GEO accession code GSE166041 and GSE82185.