Table 2.
Two-sample MR estimates of relationship between genetically predicted circulating leptin/sOB-R levels and SCZ.
| Exposure | Method | N | OR | p |
|---|---|---|---|---|
| Leptin | IVW_FE | 4 | 1.98 | 1.97E−03 |
| Leptin | IVE_RE | 4 | 1.98 | 0.10 |
| Leptin | MR Egger | 4 | 44.8 | 0.56 |
| Leptin | Weighted median | 4 | 1.24 | 0.49 |
| sOB-R | IVW_FE | 3 | 0.98 | 0.06 |
| sOB-R | MR Egger | 3 | 0.99 | 0.76 |
| sOB-R | Weighted median | 3 | 0.98 | 0.08 |
In this study, we performed MR analyses using circulating leptin/sOB-R levels as exposure and SCZ as outcome.
OR, odds ratio; N, number of single-nucleotide polymorphisms (SNPs) used in the MR analyses; IVW_FE, inverse-variance-weighted (IVW) fixed-effects model; IVW_RE, inverse-variance-weighted (IVW) random-effects model; MR, Mendelian randomization; sOB-R, soluble leptin receptor; SCZ, schizophrenia.