TABLE 3.

Univariate and multivariate analyses of overall survival.

Variable	Univariate				Multivariate
	5-year OS (%)	95% CI		p	Hazard ratio	95% CI	p
Gender				0.001
Male	61.8	58.5–65.0			Ref
Female	71.6	67.9–75.3			0.7	0.6–0.9	0.005
Age				0.285
<65	66.4	63.7–69.1
≥65	62.7	57.2–68.2
Smoking				0.026
No	69.6	65.9–73.3			Ref
Yes	62.5	59.2–65.8			1.1	0.9–1.4	0.268
Family History				0.667
No	65.3	62.6–68.0
Yes	67.0	60.9–73.1
Pathology
				0.134
ADC	67.2	64.1–70.3
SCC	64.0	59.7–68.3
Others	54.4	41.5–67.3
TNM stage				<0.001
I	75.9	72.8–79.0			Ref
II	65.0	59.3–70.7			1.5	1.2–1.9	0.002
III	45.0	39.9–50.1			2.7	2.2–3.2	<0.001
CEA group				<0.001
Normal preoperative CEA (A)	68.4	65.9–70.9			Ref
Normalized Postoperative CEA (B)	59.0	50.8–67.2			1.2	0.9–1.5	0.270
Elevated Postoperative CEA ©	32.4	21.8–43.0			2.0	1.5–2.7	<0.001