Table 1. Basic characteristics of the included studies.
| Author | Year | Condition treated | Number of cases (E/C) | Mean age (years) | Intervention group (azithromycin group) | Control group | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Route of administration | Dose and course of treatment | Adverse reactions | Therapeutic drug | Adverse reactions | ||||||
| Stokholm et al. (8) | 2016 | Asthma-like symptoms | 72/79 | 1–3 | Oral | 10 mg/kg per day for 3 days | 18 cases. The details were unknown | Placebo for 3 days | 24 cases. The details were unknown | |
| Li et al. (9) | 2019 | Tonsillitis in children | 83/79 | 5.6±2.3 | Oral | 10 mg/kg per day for 3 days | 2 cases: 1 diarrhea, 1 nausea | Amoxicillin 30 mg/kg per day for 10 days | 9 cases: 4 diarrhea, 2 rash, 3 nausea | |
| Goyal et al. (10) | 2018 | Bronchiectasis | 82/97 | 1–19 | Oral | 5 mg/kg per day for 21 days | 17 cases: 6 diarrhea, 2 rash, 9 nausea and vomiting | Amoxicillin-clavulanate 22.5 mg/kg, twice daily for 21 days | 23 cases: 15 diarrhea, 0 rash, 8 nausea and vomiting | |
| Sié et al. (11) | 2020 | Malaria | 230/220 | 1–4 | Oral | 20 mg/kg per day for 14 days | 35 cases: 0 abdominal pain, 18 diarrhea, 0 rash, 16 nausea and vomiting, 1 constipation | Placebo for 14 days | 21 cases: 2 abdominal pain, 13 diarrhea, 1 rash, 4 nausea and vomiting, 1 constipation | |
| Mandhane et al. (12) | 2017 | Acute asthma | 140/139 | 1–5 | Oral | 5 mg/kg per day for 5 days | 80 cases: 23 abdominal pain, 42 diarrhea, 26 rash, 22 nausea and vomiting, 8 headache | Placebo for 5 days | 97 cases: 34 abdominal pain, 44 diarrhea, 26 rash, 29 nausea and vomiting, 14 headache | |
| Oldenburg et al. (13) | 2018 | NA | 571/1142 | 1–5 months | Oral | 20 mg/kg for 14 days | 169 cases. The details were unknown | Placebo for 14 days | 391 cases. The details were unknown | |
| Mitjà et al. (14) | 2012 | Yaws | 110/113 | 0.5–15 | Oral | 30 mg/kg | 10 cases | Intramuscular injection of 50,000 units per kg benzathine benzylpenicillin | 8 cases | |
| Saiman et al. (15) | 2010 | CF patients with Chronic Pseudomonas aeruginosa infection | 131/129 | 6–18 | Oral | 250 mg 3 days per week for 6 months | 94 cases: 17 abdominal pain, 25 diarrhea, 22 nausea and vomiting, 30 headache | Placebo for 6 months | 127 cases: 20 abdominal pain, 36 diarrhea, 31 nausea and vomiting, 40 headache | |
| Wang et al. (16) | 2018 | Cholera | 91/89 | 1–5 | Intravenous injection | 30 mL/kg per day | 113 cases: 81 vomiting, 30 abdominal pain, and 2 abdominal distension | Ciprofloxacin 20 mg/kg | 115 cases: 78 vomiting, 32 abdominal pain, 5 abdominal distension | |
E, experiment; C, control; NA, not available; CF, cystic fibrosis.