TABLE 5.
Pearson correlations coefficients (r) and FDR-corrected P values for correlations between changes in serum protein concentrations and changes in the asthma control parameter (ACQ) from baseline to 6 mo1
| Serum protein | r | FDR P value |
|---|---|---|
| Th2-related | ||
| IL-4 | 0.27 | 0.12 |
| IL-5 | 0.31 | 0.102 |
| IL-13 | 0.48 | <0.052 |
| Eotaxin | 0.08 | 0.62 |
| Th1-related | ||
| IL-12P40 | 0.34 | 0.082 |
| IL-12P70 | 0.30 | 0.102 |
| IFN-γ | 0.32 | 0.102 |
| IP-10 | 0.34 | 0.082 |
| MIG/CXCL9 | 0.20 | 0.26 |
| Th17-related | ||
| IL-17F | 0.14 | 0.43 |
| IL-17 | 0.10 | 0.57 |
| Regulatory | ||
| IL-10 | 0.29 | 0.11 |
| Inflammatory | ||
| IL-1α | 0.40 | 0.072 |
| IL-1β | 0.19 | 0.30 |
| IL-2 | 0.37 | 0.072 |
| IL-6 | 0.36 | 0.072 |
| IL-8 | 0.10 | 0.58 |
| IL-15 | 0.39 | 0.072 |
| IFN-β | 0.07 | 0.67 |
| TGF-α | 0.36 | 0.072 |
| TGF-β | 0.12 | 0.49 |
| TNF-α | 0.32 | 0.102 |
| MIP-1α | 0.25 | 0.17 |
| MIP-1β | 0.21 | 0.26 |
| MCP-1 | 0.28 | 0.11 |
| MCP-3 | 0.34 | 0.082 |
| RANTES | 0.24 | 0.19 |
| Resistin | 0.18 | 0.30 |
| CD40L | −0.06 | 0.68 |
| Adhesion | ||
| ICAM-1 | −0.05 | 0.74 |
| VCAM-1 | 0.09 | 0.61 |
| Inflammation-associated growth factors | ||
| IL-7 | 0.29 | 0.11 |
| VEGF | 0.18 | 0.30 |
| G-CSF | 0.16 | 0.38 |
| GM-CSF | 0.40 | 0.072 |
| NGF | 0.22 | 0.22 |
| Other growth factors | ||
| LIF | 0.22 | 0.22 |
| SCF | 0.29 | 0.102 |
| FGFβ | 0.31 | 0.102 |
| HGF | 0.23 | 0.19 |
| Other | ||
| Leptin | 0.12 | 0.49 |
| PAI-1 | 0.25 | 0.17 |
| FASL | 0.29 | 0.112 |
| ENA-78 | 0.23 | 0.20 |
| PDGFBB | 0.34 | 0.082 |
| TRAIL | 0.17 | 0.34 |
| IL-1RA | 0.33 | 0.082 |
ACQ, Asthma Control Questionnaire; DASH, Dietary Approaches to Stop Hypertension; ENA-78, epithelial-derived neutrophil-activating peptide 78; FASL, soluble Fas ligand; FDR, false discovery rate; FGF, fibroblast growth factor; G-CSF, granulocyte colony stimulatory factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; HGF, hepatocyte growth factor; ICAM-1, soluble intercellular adhesion molecule 1; IP-10, interferon γ–induced protein 10; LIF, leukemia inhibitory factor; MCP, macrophage colony-stimulating factor; MIG/CXCL9, monokine induced by γ interferon; MIP, macrophage inflammatory protein; NGF, nerve growth factor; PAI-1, plasminogen activator inhibitor 1; PDGFBB, platelet-derived growth factor-BB; RANTES, regulated on activation, normal T-cell expressed and secreted; SCF, stem cell factor; TGF, transforming growth factor; Th, T-helper; VCAM-1, soluble vascular cell adhesion molecule 1; VEGF, vascular endothelial growth factor.
Indicates correlation coefficients with original P values of <0.05.