Table 1.
Comparison of participant characteristics by cardiovascular disease endpoints.
| Women with CVD (n = 186) | Women without CVD (n = 721) | Number with missing data, n (%) | p value | |
|---|---|---|---|---|
| Demographic characteristics | ||||
| Age, y | 31.0 [28.0, 34.0] | 30.0 [28.0, 34.0] | 0 | 0.385 |
| Gestational week at delivery, w | 37.0 [32.0, 38.0] | 38.0 [35.0, 39.0] | 0 | <0.001 |
| *Multifetation, n (%) | 11 (5.90) | 57 (7.90) | 0 | 0.358 |
| †Multiple pregnancy, n (%) | 107 (57.5) | 382 (53.0) | 0 | 0.268 |
| ‡Parity, n (%) | 143 (76.9) | 562 (77.9) | 0 | 0.755 |
| Gestational diabetes mellitus, n (%) | 46 (24.7) | 157 (21.8) | 0 | 0.389 |
| Pre-pregnancy risk factor | ||||
| Hypertension, n (%) | 42 (22.6) | 122 (16.9) | 0 | 0.074 |
| Diabetes mellitus, n (%) | 8 (4.30) | 25 (3.50) | 0 | 0.588 |
| Body mass index, kg/m2 | 24.2 [21.1, 26.6] | 23.7 [20.5, 27.0] | 0 | 0.985 |
| Blood pressure | ||||
| Systolic BP at eligibility, mmHg | 160 [141, 180] | 146 [131, 160] | 0 | <0.001 |
| Diastolic BP at eligibility, mmHg | 100 [90, 110] | 90 [80, 101] | 0 | <0.001 |
| Laboratory data | ||||
| platelet count, (× 109 /L) | 236 [195, 291] | 230 [193, 272] | 0 | 0.032 |
| neutrophil count, (× 109/L) | 11.3 [8.04, 14.0] | 9.53 [7.36, 12.1] | 0 | <0.001 |
| monocyte count, (× 109/L) | 0.69 [0.53, 0.88] | 0.60 [0.47, 0.78] | 0 | 0.002 |
| Hemoglobin, g/L | 124.5 [115.0, 135.0] | 123.0 [115.0, 133.0] | 0 | 0.142 |
| Red blood cell specific volume, (%) | 38.0 [35.0, 41.0] | 37.1 [34.9, 40.0] | 0 | 0.022 |
| Glucose, mmol/L | 6.45 [5.13, 7.63] | 5.67 [4.77, 6.78] | 0 | <0.001 |
| Aspartate aminotransferase, U/L | 20.0 [16.0,29.0] | 20.0 [17.0, 27.0] | 0 | 0.104 |
| Alanine aminotransferase, U/L | 13.0 [9.00, 20.0] | 13.0 [9.00, 20.0] | 0 | 0.191 |
| Alkaline phosphatase, U/L | 138.0 [97.3, 185.0] | 153.0 [114.0, 197.0] | 16 (1.8) | 0.027 |
| Urea nitrogen, mmol/L | 5.30 [4.00, 7.40] | 4.40 [3.60, 5.70] | 0 | <0.001 |
| Uric acid, μmol/L | 391.6 [311.1, 484.4] | 347.7 [276.7, 440.0] | 0 | <0.001 |
| Creatinine, μmol/L | 62.1 [50.8, 76.6] | 56.7 [48.6, 67.5] | 0 | <0.001 |
| 24h proteinuria, mg | 922.2 [406.7, 4101.3] | 551.3 [354.2, 1667.9] | 0 | <0.001 |
| Lactate dehydrogenase, U/L | 212.0 [170.3,304.8] | 197.0 [165.0, 259.0] | 44 (4.9) | 0.015 |
| C-reactive protein, mg/l | 4.95 [2.34, 10.69] | 3.64 [1.76, 9.13] | 143 (15.8) | 0.110 |
| Type B natriuretic peptide | 181.5 [63.8, 430.8] | 128.0 [50.0,353.5] | 295 (32.5) | 0.145 |
| Homocysteine, umol/l | 6.80 [5.70, 8.80] | 6.90 [5.80, 8.60] | 272 (30.0) | 0.577 |
| D-Dimer, ng/ml | 870.0 [538.0,2423.0] | 750.0 [444.5, 1882.0] | 157 (17.3) | 0.114 |
| Fibrinogen, g/L | 4.42 [3.89, 4.96] | 4.33 [3.80, 4.83] | 157 (17.3) | 0.470 |
| Interventions, n (%) | 109 (58.6) | 406 (56.3) | 0 | 0.574 |
| Umbilical artery systolic/diastolic ratio | 2.50 [2.30, 2.90] | 2.40 [2.20, 2.70] | 29 (3.2) | 0.061 |
Values are interquartile range.
*
Multifetation was defined as multiple births gestation.
†
Multiple pregnancy was defined as the number of pregnancies ≥2 times.
‡
Parity was defined as no previous births. Interventions, antihypertensive medications administered and/or MgSO4 administered; Umbilical artery systolic/diastolic ratio, the ratio of peak systolic velocity of umbilical artery blood flow to minimum end-diastolic velocity (umbilical artery Doppler).