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. 2021 Oct 27;12:774026. doi: 10.3389/fimmu.2021.774026

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Copyright © 2021 Marzi, Jankeel, Menicucci, Callison, O’Donnell, Feldmann, Pinski, Hanley and Messaoudi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VSV-MARV vaccination protects NHPs within 7 days from lethal challenge. (A) Survival and (B) clinical score of vaccinated and challenged NHPs are shown. Statistical significance among survival rates was determined using Mantel-Cox test. Levels of (C) platelets, (D) MARV viremia, (E) aspartate aminotransferase (AST) and (F) alkaline phosphatase (ALP) in the blood or serum of MARV-infected NHPs. Mean and standard deviation (SD) are depicted in (C). Statistical significance among groups was determined using two-way ANOVA with Tukey’s multiple comparisons. Statistical significance is indicated as **p < 0.01, and *p < 0.05.