Table 1.

Comparison of DEGs relative to 0 DPV.

Pairwise comparison	No. upregulated DEGs	No. downregulated DEGs
Challenge 14 DPV
3 DPC vs. 0 DPV	58	7
6 DPC vs. 0 DPV	40	4
9 DPC vs. 0 DPV	71	2
14 DPC vs. 0 DPV	81	15
21 DPC vs. 0 DPV	47	4
42 DPC vs. 0 DPV	94	55
Challenge 7 DPV
3 DPC vs. 0 DPV	45	19
6 DPC vs. 0 DPV	10	23
9 DPC vs. 0 DPV	101	604
14 DPC vs. 0 DPV	18	12
21 DPC vs. 0 DPV	13	23
42 DPC vs. 0 DPV	21	80
Challenge 3 DPV
3 DPC vs. 0 DPV	42	2
6 DPC vs. 0 DPV	197	588
9 DPC vs. 0 DPV	47	41
14 DPC vs. 0 DPV	25	5
21 DPC vs. 0 DPV	35	15
42 DPC vs. 0 DPV	127	118

DEGs are defined as those with at least 2-fold change in expression relative

to 0 DPV with an FDR-corrected p value <0.05 and an average RPKM of 5.

The DEGs listed are protein-coding and human homolog genes.

DEG, differentially expressed genes; DPV, days post-vaccination; No., number; DPC, days post-challenge.