Table 4.
Diagnostic performance of different sizes of 5 guidelines.
| Method | Cut-off | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | AUC | |
|---|---|---|---|---|---|---|---|---|
| ACR-TIRADS | ≤10mm | 5 | 70.4 (58.4-80.7) |
68.4 (59.9-75.9) |
53.2 (46.0-60.2) |
81.9 (75.6-86.8) |
69.1 (62.3-75.2) |
0.746 (0.681-0.811) |
| >10mm | 5 | 74.6 (69.7-79.2) |
70.1 (66.0-74.0) |
62.0 (58.5-65.3) |
80.9 (77.8-83.7) |
71.9 (68.8-74.9) |
0.767 (0.737-0.798) |
|
| P value | 0.025 | 0.235 | 0.537 | 0.052 | 0.859 | 0.513 | ||
| Kwak-TIRADS | ≤10mm | 4C | 80.3 (69.1-88.8) |
63.3 (54.7-71.3) |
52.8 (46.6-58.9) |
86.3 (79.5-91.1) |
69.1 (62.3-75.2) |
0.780 (0.719-0.840) |
| >10mm | 4C | 91.8 (88.4-94.5) |
61.7 (57.5-65.8) |
60.2 (57.5-62.9) |
92.3 (89.3-94.5) |
73.4 (70.3-76.3) |
0.790 (0.761-0.819) |
|
| P value | 0.007 | 0.801 | 0.185 | 0.094 | 0.240 | 0.721 | ||
| EU-TIRADS | ≤10mm | 5 | 77.5 (66.0-86.5) |
60.4 (51.78- 68.6) |
50.0 (44.0-56.0) |
84.0 (77.0-89.1) |
66.2 (59.4-72.6) |
0.726 (0.659-0.793) |
| >10mm | 5 | 90.3 (86.8-93.3) |
54.1 (49.9-58.3) |
55.5 (53.0-57.9) |
89.9 (86.5-92.6) |
68.2 (65.0-71.2) |
0.734 (0.702-0.767) |
|
| P value | 0.004 | 0.216 | 0.344 | 0.149 | 0.638 | 0.794 | ||
| C-TIRADS | ≤10mm | 4C | 69.2 (56.8-80.7) |
94.2 (89.0-97.5) |
84.0 (72.3-91.4) |
81.9 (77.3-85.7) |
82.4 (76.5-87.3) |
0.833 (0.776-0.890) |
| >10mm | 4C | 77.1 (71.8-82.0) |
79.2 (75.5-82.5) |
67.1 (63.0-70.9) |
79.2 (76.5-81.7) |
74.5 (71.5-77.3) |
0.808 (0.780-0.836) |
|
| P value | 0.254 | <0.001 | 0.023 | 0.527 | 0.021 | 0.411 | ||
| KTA/KSThR-TIRADS | ≤10mm | 5 | 74.7 (62.9-84.2) |
65.5 (56.9-73.3) |
52.5 (45.8-59.0) |
83.5 (76.9-88.5) |
68.6 (61.8-74.8) |
0.750 (0.685-0.814) |
| >10mm | 5 | 83.1 (78.7-86.9) |
67.0 (62.9-71.0) |
61.4 (58.3-64.4) |
86.3 (83.1-88.9) |
73.3 (70.2-76.1) |
0.779 (0.749-0.809) |
|
| P value | 0.132 | 0.803 | 0.121 | 0.560 | 0.201 | 0.365 | ||
95% confidence intervals are in parentheses; PPV, positive predictive value; NPV, negative predictive value; AUC, area under the receiving operator characteristics curve; P value, Compared with C-TIRADS.