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. 2021 Oct 27;11:763468. doi: 10.3389/fonc.2021.763468

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Copyright © 2021 Sakai, Sakurai, De Velasco, Nagai, Chikugo, Ueshima, Kura, Takahama, Hayashi, Nakagawa, Kudo and Nishio

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biological trends for I-irAE, I-UC, A-irAE, and A-UC regions compared with normal samples. The size and color of each tile reflect the p value (−log) and the z-score, which reflect the overall predicted activation state (<0: inhibited, >0: activated), respectively, compared with the normal sample. The intensity scale of the z-score ranges from dark blue (low value) to dark orange (high value). (A) Featured canonical pathways of inactive irAE (n = 14) and normal control (n = 3). (B) Featured canonical pathways of inactive UC (n = 9) and normal control (n = 3). (C) Featured canonical pathways of active irAE (n = 15) and normal control (n = 3). (D) Featured canonical pathways of active UC (n = 9) and normal control (n = 3).