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. 2021 Oct 27;11:763468. doi: 10.3389/fonc.2021.763468

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Copyright © 2021 Sakai, Sakurai, De Velasco, Nagai, Chikugo, Ueshima, Kura, Takahama, Hayashi, Nakagawa, Kudo and Nishio

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation heatmap of relative abundance of 50 most abundant inferred KEGG orthology pathways selected by Piphillin in I-irAE (n = 14), I-UC (n = 9), A-irAE (n = 15), A-UC (n = 9), and normal samples (n = 3) using Pearson’s correlation metric. Values were scaled to z-score and colors correspond to correlation, red = high correlation and blue = low correlation. Dendrograms represent average distance. Two main clusters were identified, and samples characterized by inflamed (A-irAE and A-UC) and non-inflamed (I-irAE, I-UC, and normal) status were correlated accordingly.