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. 2021 Oct 27;11:722624. doi: 10.3389/fonc.2021.722624

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Copyright © 2021 Ding, Xu, Deng, Ma, Zhang, He, Liu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression status and prognostic value of RPN1 in BC. (A) Gene expression analysis of RPN1 in BC tissues and normal breast tissues according to TCGA database and GEO database (GSE42568). (B) Gene expression analysis of RPN1 in different subtypes of BC according to TCGA database and GEO database (GSE47561). (C) Representative IHC staining of RPN1 expression in BC tissues and normal tissues according to the HPA database. (D) The protein expression of RPN1 in BC tissues and normal tissues in CPTAC samples according to the UALCAN database. Z-values represented standard deviations from the median across samples. (E) The promoter methylation level of RPN1 in BC tissues and normal tissues in TCGA samples according to the UALCAN database. The Beta value indicated the level of DNA methylation ranging from 0 (unmethylated) to 1 (fully methylated). (F–I) RFS for RPN1 in BLBC, Luminal A, Luminal B, and HER2-enriched BC. P<0.05 was considered statistically significant. **P < 0.01, ***P < 0.001 and ****P < 0.0001.