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. 2021 Oct 27;11:722624. doi: 10.3389/fonc.2021.722624

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Copyright © 2021 Ding, Xu, Deng, Ma, Zhang, He, Liu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RPN1 knockdown inhibited the growth and invasion of BLBC cells. (A) RPN1 was knocked down (scramble was the control). The expression of RPN1 was detected by qRT-PCR in SUM159 and SUM149. (B, C) MTT assay and Colony formation assay were used to measure the cell proliferation ability. (D) Cell cycle distribution analyzed by flow cytometry in SUM159 cells. (E, F) Wound healing assay and transwell assay were used to measure the cell migration and invasion ability. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001.