Table 1.
The relationship between the OST subunits and the clinicopathologic parameters of BC (bc-GenExMiner v4.5).
| RPN1 | RPN2 | STT3A | STT3B | DDOST | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Comp. | P | Comp. | P | Comp. | P | Comp. | P | Comp. | P | ||
| Age | ≤51 | 0.8184 | ↑ | 0.0019 | 0.1950 | 0.0578 | 0.4482 | ||||
| >51 | |||||||||||
| ER (IHC) | Negative | ↑ | <0.0001 | ↑ | 0.0020 | ↑ | <0.0001 | 0.2391 | ↑ | <0.0001 | |
| Positive | |||||||||||
| PR (IHC) | Negative | ↑ | <0.0001 | ↑ | 0.0003 | 0.1242 | 0.3620 | ↑ | <0.0001 | ||
| Positive | |||||||||||
| HER2 (IHC) | Negative | 0.0661 | ↑ | <0.0001 | 0.1040 | ↑ | <0.0001 | 0.0631 | |||
| Positive | |||||||||||
| Nodal status | Negative | 0.9624 | 0.1551 | ↑ | 0.0289 | <0.0001 | 0.5209 | ||||
| Positive | ↑ | ||||||||||
| Intrinsic molecular subtypes | Total | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | |||||
| Basal-like vs Luminal A | > | <0.0001 | > | <0.0001 | > | <0.0001 | > | <0.0001 | > | <0.0001 | |
| Basal-like vs Luminal B | > | <0.0001 | < | <0.0001 | > | <0.0001 | < | <0.0001 | > | <0.0001 | |
| Basal-like vs HER2-E | > | <0.05 | < | <0.0001 | = | >0.01 | < | <0.0001 | > | <0.0001 | |
| Luminal B vs Luminal A | > | <0.0001 | > | <0.0001 | < | <0.001 | > | <0.0001 | > | <0.0001 | |
| Luminal B vs HER2-E | = | >0.01 | < | <0.0001 | < | <0.0001 | < | <0.001 | < | <0.0001 | |
| HER2-E vs Luminal A | > | <0.0001 | > | <0.0001 | > | <0.0001 | > | <0.0001 | > | <0.0001 | |
| Basal-like status | Basal | ↑ | <0.0001 | 0.4492 | ↑ | <0.0001 | 0.2047 | ↑ | <0.0001 | ||
| None | |||||||||||
| SBR | Total | <0.0001 | <0.0001 | 0.0012 | <0.0001 | <0.0001 | |||||
| SBR2 vs SBR1 | > | <0.0001 | > | <0.0001 | = | >0.01 | > | <0.01 | > | <0.01 | |
| SBR3 vs SBR1 | > | <0.0001 | > | <0.0001 | > | <0.01 | > | <0.0001 | > | <0.0001 | |
| SBR3 vs SBR2 | > | <0.0001 | > | <0.0001 | > | <0.01 | > | <0.01 | > | <0.0001 | |
| NPI | Total | <0.0001 | 0.0015 | 0.2014 | 0.0024 | 0.0715 | |||||
| NPI2 vs NPI1 | > | <0.001 | > | <0.01 | = | >0.01 | > | <0.01 | = | >0.01 | |
| NPI3 vs NPI1 | > | <0.001 | = | >0.01 | = | >0.01 | = | >0.01 | = | >0.01 | |
| NPI3 vs NPI2 | = | >0.01 | = | >0.01 | = | >0.01 | = | >0.01 | = | >0.01 | |
The data with statistical significance (P<0.01) were marked in bold text.
Comp, comparison; IHC, immunohistochemical; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; HER2-E, HER2-enriched; SBR, Scarff Bloom & Richardson grade; NPI, Nottingham Prognostic Index.