FIGURE 5.
Hair cell protein expression and distortion product otoacoustic emission (DPOAE) study. Representative DPOAE waveforms of NeflCreER/+;iDTR+/– mice treated with either diphtheria toxin (DT) or vehicle are shown in (A). In the quantitative study, DPOAE measurements at 4 weeks old did not show a significant difference between the DT and vehicle treatments at 16 (A1) or 24 kHz (A2) in the P14 or P21 groups (two-way ANOVA: p > 0.05, n = 6 mice/group). In the surface preparation of NeflCreER/+;iDTR+/– mice treated with either DT or vehicle on P14, the numbers of myosin VIIa-expressing cells are statistically insignificant (B,B1; ANOVA: p > 0.05, n = 5 mice/group). n.s. statistically insignificant. Scale, 25 μm in (B).