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. 2021 Nov 4;9(11):e002837. doi: 10.1136/jitc-2021-002837

Figure 4.

Figure 4

BXCL701 increases tumor levels of chemoattractants CXCL9/10 and CXCR3 + cells. (A) Heatmap showing average fold change of cytokine concentration in mT3-2D tumors treated with BXCL701. Each value is the average from two timepoints: week 4 and week 5 of treatment. Each timepoint consisted of three to four pooled tumors. (B) Representative IHC images and quantification of CXCR3+ staining in tumors treated with PBS or BXCL701 for 4 weeks. Each point represents the average value from one tumor. (*p<0.05 as determined by unpaired two-tailed t-test). (C) Representative IHC images of CD4+, CD8+ and NKp46+ staining in tumors treated with PBS or BXCL701. (D) Quantification of CD4+, CD8+ and NKp46+ staining in tumors treated with PBS or BXCL701 for 7 days and 28 days. Each point represents one tumor/mouse. (ns=nonsignificant, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 as determined by unpaired two-tailed t-test). IHC, immunohistochemistry; PBS, phosphate-buffered saline.