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Schematic illustration underlying the mechanism of ATO’s effect on the circHIPK3/miR-149-5p/FOXO1/VEGF functional module. CircHIPK3 might act as a sponge for the FOXO1-targeting miR-149-5p, leading to the downregulation of downstream VEGF. These networked factors mainly form a functional module regulating angiogenesis in RA-FLS, and the expression of this functional module could be significantly downregulated by ATO, ultimately inhibiting angiogenesis.
