Table 1.

PICOS criteria.

	Prevalence of ASD	Prevalence of co-morbidities
Population	Pediatric population (from 2 to <18y) with ASD according to DSM-IV/DSM-5	Pediatric population (from 2 to <18y) with ASD according to DSM-IV/DSM-5
Intervention	Not applicable	Not applicable
Comparator	Not applicable	Not applicable
Outcomes	• Prevalence • Trend overtime	• Prevalence for the following co-morbidities: ADHD, anxiety, depressive disorders, epilepsy, ID, sleep disorders, sight/hearing impairment/loss, GI,
Study designs	Observational studies	Observational studies