Table 7.
Epitope conservation of VSP family.
| T- cell epitope | |||||||
|---|---|---|---|---|---|---|---|
| Predicted epitope | Protein match | Epitope sequence | Position | Identity (%) | Host- homology >35% | ||
| Human | Mouse | ||||||
| 1 | LSTGAIAGISVAAFV | VSP 5G8 | LSSGAIAGISVAVIV | 574-588 | 80 | No | No |
| VSPH7 | LSSGAIAGISVAVIV | 524-538 | 80 | No | No | ||
| VSP9B10 | LSAGAIAGIAVAVII | 706-720 | 66.67 | No | No | ||
| VSP1267 | LSTGAIAGISVAAFV | 563-577 | 100 | No | No | ||
| VSP AS8 | LSTGAIAGISVAVVA | 583-597 | 80 | No | No | ||
| VSP5 | LSSGAIAGISVAVIA | 147-161 | 73.33 | Yes (46%) | No | ||
| TSA417 | LSTGAIAGISVAVIV | 574-588 | 86.67 | No | No | ||
| 2 | SRCNTGFVPINGQCA | VSP9B10 | SRCNTGFVPINGQCA | 51-65 | 100 | Yes (40%) | No |
| VSP1267 | MQCNQGKVPINGICT | 39-53 | 60 | No | No | ||
| 3 | PVLCYLVRDSASVNK | VSP 5G8 | PVLCYLVRDSASVNK | 557-571 | 100 | No | No |
| VSP9B10 | SVLCYLVQSGENTNK | 689-703 | 53.33 | No | No | ||
| TSA417 | SVLCYLIKDSGSTNK | 663-677 | 66.67 | No | No | ||
| 4 | VAVILQIARAACTPG | VSP 5G8 | VAVILQIARAACTPG | 8-22 | 100 | No | No |
| TSA417 | AIVILQLARTACTQE | 8-22 | 60 | No | No | ||
| 5 | QAAQGYFVPPGADAS | VSP9B10 | QAAQGYFVPPGADAS | 123-137 | 100 | No | No |
| TSA417 | EAAPGYFAPVGAANT | 115-129 | 53.33 | No | No | ||
| B- cell epitope | |||||||
| Predicted epitope | Protein match | Epitope sequence | Position | Identity (%) | Host- homology >35% | ||
| Human | Mouse | ||||||
| 1 | CATCTTAASTCSTCAD | VSP 5G8 | CATCTTA AS TCSTCAD | 505-520 | 100 | Yes (37%) | Yes (37%) |
| VSP9B10 | CATCAGS ASNCDTCST | 635-650 | 56.25 | Yes (50%) | Yes (43%) | ||
| TSA417 | CETCNGAATTCKACAT | 608-623 | 56.25 | Yes (50%) | Yes (50%) | ||
| 2 | AQGYFVPPGADASHQS | VSP9B10 | AQGYFV PP GAD AS HQS | 125-140 | 100 | No | No |
| TSA417 | APGYFAPVGAANTEQS | 117-132 | 56.25 | No | No | ||
| 3 | SCAPPTTPPGPVTCYV | VSP 5G8 | SCAAPSGSTGP VLCYL | 547-562 | 56.25 | No | No |
| VSP9B10 | NCA PP LNNK GSVLCYL | 679-694 | 50 | No | No | ||
| VSP AS8 | SCA PPAGSSGP VTCYV | 545-560 | 75 | No | No | ||
| VSP5 | SCA PP TT PPGP VTCYV | 114-129 | 100 | Yes (37%) | No | ||
| TSA417 | NCA PPPNNKGSVLCYL | 653-668 | 50 | No | No | ||
| 4 | PGSTVCVTAPTGGTCT | VSP 5G8 | PGSTVCVTAPTGGTCT | 438-453 | 100 | Yes (37%) | No |
| VSPH7 | PGNTLCTTADAGKCTT | 408-423 | 50 | No | Yes (37%) | ||
| VSP1267 | AGRDVSVCTATGGKCT | 406-421 | 50 | No | No | ||
| VSP AS8 | PGSSVCTAAQNKGQCQ | 464-479 | 50 | No | No | ||
| TSA417 | PGKTVCISAPNGGTCQ | 543-558 | 68.75 | No | No | ||
| 5 | KGATASDCTACPAGRA | VSP 5G8 | KGAT AS DCTACPAGRA | 329-344 | 100 | Yes (50%) | Yes (43%) |
| TSA417 | SAGT AS DCTECPTGKA | 433-448 | 62.50 | Yes (43%) | Yes (37%) | ||
| 6 | TDCPAGTYAVSGDSGS | VSPH7 | QDCPAGTYADSNVCKP | 272-287 | 56.25 | Yes (62%) | Yes (50%) |
| VSP1267 | TDCPAGTYAVSGDSGS | 303-318 | 100 | Yes (50%) | Yes (57%) | ||
Red letters correspond to amino acids residues other than the predicted epitope.
Bold and underline letters correspond to dipeptide regions related to activation of specific-isotype (IgG and IgA) antibody response.