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. 2021 Mar 29;190(9):1793–1802. doi: 10.1093/aje/kwab086

Table 3.

Associations Between Creatinine-Standardized and ln-Transformed Urinary Organophosphate Ester Metabolites at 16 Weeks and Maternal Thyroid Hormone Levels at 16 Weeks (n = 298), Health Outcomes and Measures of the Environment Study, 2003–2006a

Parameter FT3, pg/mL FT4, ng/dL TT3, ng/dL TT4, μg/dL Log TSH, μIU/mL
Estimate 95% CI Estimate 95% CI Estimate 95% CI Estimate 95% CI Estimate 95% CI
BCEP, quartile
 1 0 Referent 0 Referent 0 Referent 0 Referent 1.00 Referent
 2 −0.05 −0.18, 0.07 −0.01 −0.05, 0.03 −8.02 −18.20, 2.15 −0.52 −1.32, 0.28 0.98 0.71, 1.36
 3 0.04 −0.08, 0.16 0.01 −0.03, 0.05 −1.67 −11.85, 8.52 −0.42 −1.22, 0.38 0.96 0.69, 1.33
 4 −0.03 −0.15, 0.10 0.00 −0.05, 0.05 −4.69 −14.68, 5.31 −0.45 −1.24, 0.33 1.20 0.89, 1.65
  P for trend 0.82 0.83 0.65 0.46 0.18
BDCIPP, quartile
 1 0 Referent 0 Referent 0 Referent 0 Referent 1.00 Referent
 2 0.15 0.03, 0.27 0.02 −0.02, 0.06 8.43 −1.68, 18.54 0.25 −0.55, 1.04 1.01 0.73, 1.40
 3 0.06 −0.06, 0.19 0.02 −0.03, 0.06 8.73 −1.59, 19.05 0.27 −0.55, 1.08 1.10 0.79, 1.54
 4 0.06 −0.06, 0.19 −0.03 −0.07, 0.01 5.52 −4.68, 15.72 0.07 −0.96, 0.72 1.12 0.81, 1.56
  P for trend 0.93 0.04 0.70 0.91 0.48
DPHP, quartile
 1 0 Referent 0 Referent 0 Referent 0 Referent 1.00 Referent
 2 0.05 −0.08, 0.17 −0.01 −0.05, 0.03 −0.38 −10.83, 10.08 0.25 −0.56, 1.07 1.22 0.88, 1.70
 3 0.02 −0.11, 0.14 0.01 −0.03, 0.05 −0.74 −11.01, 9.54 0.40 −0.40, 1.20 0.95 0.68, 1.32
 4 0.03 −0.10, 0.15 −0.01 −0.06, 0.03 −0.79 −10.93, 9.35 0.15 −0.64, 0.94 0.92 0.66, 1.26
 P for trend 0.89 0.56 0.89 0.92 0.27
DNBP, quartile
 1 0 Referent 0 Referent 0 Referent 0 Referent 1.00 Referent
 2 0.04 −0.08, 0.17 −0.02 −0.06, 0.02 0.70 −9.70, 11.10 −0.44 −1.25, 0.37 0.87 0.62, 1.21
 3 0.03 −0.09, 0.16 0.01 −0.04, 0.05 −0.13 −10.78, 11.10 −0.64 −1.48, 0.18 1.10 0.78, 1.54
 4 −0.06 −0.21, 0.09 0.01 −0.06, 0.04 −0.50 −11.23, 10.23 −0.32 −1.15, 0.52 1.01 0.72, 1.42
  P for trend 0.25 0.48 0.87 0.57 0.62

Abbreviations: BCEP, bis-2-chloroethyl phosphate; BDCIPP, bis(1,3-dichloro-2-propyl) phosphate; DNBP, di-n-butyl phosphate; DPHP, diphenyl phosphate; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid-stimulating hormone; TT3, total triiodothyronine; TT4, total thyroxine.

a Models were adjusted for mother’s age at delivery, mother’s education, race, year of birth, and infant sex.