Table 4.
Associations Between Creatinine-Standardized and ln-Transformed Urinary Organophosphate Ester Metabolites at Birth by Quartile and Cord Blood Thyroid Hormones (n = 298), Health Outcomes and Measures of the Environment Study, 2003–2006a
| Parameter | FT3, pg/mL | FT4, ng/dL | TT3, ng/dL | TT4, μg/dL | Log TSH, μIU/mL | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Estimate | 95% CI | Estimate | 95% CI | Estimate | 95% CI | Estimate | 95% CI | Estimate | 95% CI | |
| BCEP, quartile | ||||||||||
| 1 | 0 | Referent | 0 | Referent | 0 | Referent | 0 | Referent | 1.00 | Referent |
| 2 | −0.05 | −0.17, 0.06 | −0.05 | −0.10, 0.01 | 0.73 | −6.38, 7.83 | −0.05 | −0.75, 0.65 | 0.83 | 0.68, 1.02 |
| 3 | −0.05 | −0.16, 0.07 | −0.02 | −0.07, 0.04 | −2.54 | −9.63, 4.55 | −0.50 | −1.20, 0.21 | 0.98 | 0.80, 1.21 |
| 4 | −0.07 | −0.18, 0.05 | 0.03 | −0.03, 0.09 | −3.09 | −10.23, 4.05 | 0.19 | −0.51, 0.90 | 1.05 | 0.85, 1.30 |
| P for trend | 0.39 | 0.05 | 0.31 | 0.41 | 0.19 | |||||
| BDCIPP, quartile | ||||||||||
| 1 | 0 | Referent | 0 | Referent | 0 | Referent | 0 | Referent | 1.00 | Referent |
| 2 | 0.04 | −0.07, 0.15 | 0.01 | −0.04, 0.07 | 3.64 | −3.40, 10.68 | −0.11 | −0.82, 0.60 | 1.26 | 1.02, 1.55 |
| 3 | −0.07 | −0.19, 0.04 | 0.02 | −0.03, 0.08 | −3.68 | −10.74, 3.38 | −0.25 | −0.96, 0.46 | 0.99 | 0.81, 1.22 |
| 4 | −0.11 | −0.22, 0.00 | 0.03 | −0.03, 0.09 | −5.18 | −12.09, 1.72 | −0.28 | −0.97, 0.41 | 1.24 | 1.01, 1.52 |
| P for trend | 0.02 | 0.35 | 0.04 | 0.48 | 0.14 | |||||
| DPHP, quartile | ||||||||||
| 1 | 0 | Referent | 0 | Referent | 0 | Referent | 0 | Referent | 1.00 | Referent |
| 2 | 0.01 | −0.10, 0.13 | −0.01 | −0.06, 0.05 | −1.36 | −8.30, 5.58 | 0.07 | −0.63, 0.77 | 1.06 | 0.86, 1.30 |
| 3 | −0.12 | −0.24, −0.01 | 0.02 | −0.04, 0.08 | −8.19 | −15.29, −1.09 | −0.35 | −1.06, 0.37 | 1.23 | 1.00, 1.52 |
| 4 | −0.07 | −0.19, 0.04 | 0.01 | −0.05, 0.06 | −4.75 | −11.75, 2.25 | −0.42 | −1.12, 0.28 | 1.25 | 1.01, 1.54 |
| P for trend | 0.17 | 0.75 | 0.22 | 0.16 | 0.04 | |||||
| DNBP, quartile | ||||||||||
| 1 | 0 | Referent | 0 | Referent | 0 | Referent | 0 | Referent | 1.00 | Referent |
| 2 | −0.04 | −0.15, 0.08 | 0.04 | −0.02, 0.09 | −2.55 | −9.72, 4.62 | −0.38 | −1.09, 0.34 | 0.98 | 0.80, 1.22 |
| 3 | −0.01 | −0.12, 0.11 | 0.05 | −0.00, 0.11 | −1.48 | −8.57, 5.62 | 0.23 | −0.47, 0.93 | 1.05 | 0.85, 1.29 |
| 4 | 0.00 | −0.12, 0.12 | 0.01 | −0.05, 0.07 | −1.75 | −9.01, 5.59 | −0.33 | −1.06, 0.41 | 1.17 | 0.94, 1.45 |
| P for trend | 0.76 | 0.91 | 0.82 | 0.56 | 0.09 | |||||
Abbreviations: BCEP, bis-2-chloroethyl phosphate; BDCIPP, bis(1,3-dichloro-2-propyl) phosphate; DNBP, di-n-butyl phosphate; DPHP, diphenyl phosphate; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid-stimulating hormone; TT3, total triiodothyronine; TT4, total thyroxine.
a Models were adjusted for mother’s age at delivery, mother’s education, race, year of birth, and infant sex.