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. 2021 Apr 14;22(5):bbab091. doi: 10.1093/bib/bbab091

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© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

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Experimental validation of biological function of isomiRs with novel seeds. (A) miR-101-3p locus is selected to perform further experimental validation. Paired analysis is performed on the canonical miRNA and its isomiR with a novel seed to show their specific expression patterns across diverse cancer types. (B) RAB11FIP1 mRNA levels are assessed after treatment with canonical miRNA or its isomiR mimics with RT-qPCR. nc, negative control. (C) Protein levels of RAB11FIP1 are evaluated after treatment with canonical miRNA or its isomiR mimics with western blotting.