Table 3.

Association of epinephrine (adrenaline) before defibrillation with survival outcomes

Outcome	Epinephrine first	Defibrillation first	Adjusted OR (95% CI)
Without hospital characteristics (n=6569):
Survival to hospital discharge	1471 (22.4)	1949 (29.7)	0.69 (0.64 to 0.74)
Survival after acute resuscitation	4055 (61.7)	4568 (69.5)	0.73 (0.67 to 0.79)
Favorable neurological survival*	985 (15.8)	1348 (21.6)	0.68 (0.61 to 0.76)
With hospital characteristics (n=6133):
Survival to hospital discharge	1378 (22.5)	1730 (28.2)	0.74 (0.68 to 0.80)
Survival after acute resuscitation	3794 (61.9)	4243 (69.2)	0.72 (0.67 to 0.78)
Favorable neurological survival†	931 (15.9)	1190 (20.4)	0.74 (0.66 to 0.83)

OR=odds ratio.

^*Sample size for analysis was 12 486 (6243 matched pairs).

^†Sample size for analysis was 11 690 (5845 matched pairs).