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. 2021 Oct;191(10):1805–1821. doi: 10.1016/j.ajpath.2021.06.006

Figure 1.

Figure 1

Retinal thickness is not affected by Capn1 deletion or diabetes. A and D: Spectral domain-optical coherence tomography images (A) and quantification of data (D) show that the deletion of Capn1 (solid red lines) alone or in conjunction with diabetes (dashed red lines) resulted in essentially no loss of retinal photoreceptors (ONL thickness) compared with nondiabetic (solid black lines) or diabetic (dashed black lines) mice. B and C: Histologic images of the entire retina (horizontal temporal-nasal orientation) stained with DAPI (B) or hematoxylin and eosin (H&E) (C) confirm a normal organization of the retinas in all four groups of mice. Data are expressed as means ± SD. n = 8 mice (16 retinas) per group (D). Scale bars: 100 μm. D, 2 months diabetic; N, nondiabetic; ONL, outer nuclear layer; WT, wild type.