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Calpain inhibition (A) and deletion (B) mitigate diabetes-induced superoxide generation. Calpain inhibitor was administered daily (i.p. injections at a dose of 10 mg/kg). Duration of diabetes was 2 months at the time of this assay, and administration of the inhibitor began promptly after the initiation of diabetes. n = 4 to 8 per group. ∗∗∗P ≤ 0.001. D, diabetic; N, nondiabetic; WT, wild type.
