Table 2.

Proteomics Data Featuring Proteins That Are Either Increased or Decreased in Diabetic Mouse Photoreceptors, Normalized by the Calpain Inhibitor

Protein ID	Protein names	Gene name	# of peptides	Mean			P value
				N	D	DT	D-N	DT-D
Proteins increased in diabetic and decreased by calpain inhibitor
O884852; O88485	Cytoplasmic dynein 1	Dync1	10	0.27	0.58	0.18	0.03	0.007
Q9CR09	Ubiquitin-fold modifier-conjugating enzyme 1	Ufc1	2	−3.92	−3.08	−1.08	0.04	0.02
Q91WL83; Q91WL8-4; Q91WL8; Q91WL8-2	WW domain-containing oxidoreductase	Wwox	4	−3.55	−1.75	−2.94	0.002	0.01
P61226; Q80ZJ12; Q8BU31	Ras-related protein Rap-2b; Ras-related protein Rap-2a; Ras-related protein Rap-2c	Rap2b; Rap2a;Rap2c	6	1.14	1.55	−0.66	0.02	0.04
O35654	DNA polymerase delta subunit 2	Pold2	3	−2.36	−1.98	−3.25	0.02	0.02
Q8BYM5	Neuroligin-3	Nlgn3	5	−1.18	−0.43	−1.10	0.02	0.02
Q91YP2	Neurolysin, mitochondrial	Nln	4	−3.39	−1.58	−3.26	0.04	0.04
Proteins decreased in diabetic and increased by calpain inhibitor
E9Q735	Ubiquitination factor E4A	Ube4a	8	0.59	0.12	0.79	0.004	0.02
P15208	Insulin receptor; insulin receptor subunit alpha; insulin receptor subunit beta	Insr	3	−3.32	−4.02	−2.78	0.03	0.01
P01872; P01872-2	Ig mu chain C region	Ighm	2	−3.56	−4.87	−2.40	0.03	0.01
Q925N0	Sideroflexin-5	Sfxn5	11	2.25	1.74	2.22	0.05	0.01
P62488	DNA-directed RNA polymerase II subunit RPB7	Polr2g	2	−0.20	−0.85	−0.08	0.03	0.01
Q8CCJ42; Q8CCJ4	APC membrane recruitment protein 2	Amer2	2	−0.32	−4.03	−0.32	0.001	0.01
Q9QZH6	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial	Ecsit	2	−3.64	−4.35	−3.13	0.02	0.02
P84099	60S ribosomal protein L19	Rpl19	3	1.30	−0.20	1.34	0.03	0.04

D, diabetic; DT, diabetic treated with calpain inhibitor; N, nondiabetic.