Figure 1.

Snapshot from Ingenuity Pathway Analysis, demonstrating key diseases and functions affected by knockdown of miR-378-3p by mirZIP-378-3p. Most highly affected pathways include those that involve cell movement and function. Key pathways are predominantly underexpressed as indicated by the blue end of the color scale of z scores that represent decrease of implicated biologic function (blue) (versus increased function in orange). A: Hematologic system development and function; B: organismal injury and abnormalities; C: cell-to-cell signaling and interaction; D: cancer; E: tissue development; F: cellular development; G: cell growth and function; H: lymphoid tissue structure; I: lipid metabolism; J: small molecule biochemistry; K: gastrointestinal disease; L: cell function and maintenance; M: hematopoiesis; N: cellular compromise; O: organismal death; P: cardiovascular disease; Q: infectious disease; R: free radical scavenging; S: cellular movement; T: inflammatory response; U: immune cell trafficking; V: cell death and survival; W: immunologic disease; X: reproductive system disease; Y: skeletal and muscular disorders; Z: endocrine system disorders; AA: embryonic development; BB: organismal development; CC: tissue morphology; DD: respiratory disease; EE: connective tissue development; FF: metabolic disease; GG: antimicrobial response; HH: inflammatory disease; II: renal and urologic disease; JJ: cell signaling; KK: cellular growth and proliferation; LL: molecular transport; MM: neurologic disease; NN: connective tissue development; OO: hepatic system disease; PP: dermatologic disease; QQ: hepatic and digestive system disease; RR: hematologic disease; SS: gene expression; TT: organ development; UU: cell migration; VV: posttranslational modification; WW: vitamin and mineral metabolism; XX: humoral immune response and hypersensitivity response; YY: carbohydrate metabolism; ZZ: protein synthesis and cellular function and maintenance.